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jakleim@asu.edu

Assoc Professor
Sch Biological & Hlth Sys Engr
Faculty
Mail Code: 9709

ECG 327 (Map)
(480)965-6832

Research Interests

Jeffrey Kleim studies how neural plasticity supports learning in the intact brain and “relearning” in the damaged or diseased brain. His research is directed at developing therapies that optimize plasticity in order to enhance recovery after stroke and Parkinson’s Disease.The brain is a highly dynamic organ that is capable of structural and functional reorganization in response to a variety of manipulations. This neural plasticity is the mechanism by which the brain encodes experience. My laboratory examines how plasticity within rat and human motor cortex supports learning in the intact brain and “relearning” after stroke. We use intracortical microstimulation in rats and transcranial magnetic stimulation in humans to examine how motor training alters the functional organization of motor cortex. This work has demonstrated that rehabilitation-dependent recovery of motor function after stroke is associated with a reorganization of movement representations in rodent motor cortex. Furthermore, there are specific behavioral and neural signals that drive both recovery and plasticity. These experiments are being used to test novel therapies for enhancing motor recovery in stroke patients.

Courses

Spring 2015

Courses Taught This Semester
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 235 Physiology for Engineers
BME 394 Special Topics
BME 484 Internship
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 494 Special Topics
BME 590 Reading and Conference
BME 593 Applied Project
BME 598 Special Topics
NEU 598 Special Topics

Fall 2014

Courses Taught This Semester
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 235 Physiology for Engineers
BME 394 Special Topics
BME 484 Internship
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 593 Applied Project

Summer 2014

Courses Taught This Semester
Course Number Course Title
BIO 495 Undergraduate Research
BME 394 Special Topics
BME 484 Internship

Spring 2014

Courses Taught This Semester
Course Number Course Title
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 484 Internship
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 494 Special Topics
BME 593 Applied Project
BME 598 Special Topics
NEU 598 Special Topics

Fall 2013

Courses Taught This Semester
Course Number Course Title
ASU 101-BME The ASU Experience
BME 100 Intro to Biomed Engineering
BME 394 Special Topics
BME 484 Internship
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 593 Applied Project

Summer 2013

Courses Taught This Semester
Course Number Course Title
BIO 495 Undergraduate Research
BME 394 Special Topics
BME 484 Internship

Spring 2013

Courses Taught This Semester
Course Number Course Title
ASU 101-BME The ASU Experience
BIO 495 Undergraduate Research
BME 101 Intro to BME I: Belief Systems
BME 102 Intro to BME II
BME 103 Intro to BME III
BME 394 Special Topics
BME 484 Internship
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 494 Special Topics
BME 593 Applied Project
BME 598 Special Topics
NEU 598 Special Topics

Fall 2012

Courses Taught This Semester
Course Number Course Title
ASU 101-BME The ASU Experience
BME 101 Intro to BME I: Belief Systems
BME 103 Intro to BME III
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 593 Applied Project

Spring 2012

Courses Taught This Semester
Course Number Course Title
AME 598 Special Topics
BIO 598 Special Topics
BME 494 Special Topics
BME 593 Applied Project
BME 598 Special Topics
NEU 598 Special Topics

Fall 2011

Courses Taught This Semester
Course Number Course Title
ASU 101-BME The ASU Experience
BME 194 Special Topics

Research Activity Research Awards

  1. Stabenfeldt,Sarah E * , Kleim,Jeffrey Allan , Kodibagkar,Vikram D , Rege,Kaushal , Sierks,Michael Richard , . Detecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out. HHS-NIH-NICHD (9/15/2014 - 8/31/2019).
  2. Kleim,Jeffrey Allan * . Investigating the role of Novel Pharmacological Agents to Enhance Recovery Following Brain Injury. (9/15/2014 - 9/14/2015).
  3. Kleim,Jeffrey Allan * . Neural Mechanisms of Compensating For Brain Damage. UTAustin (9/26/2012 - 6/30/2017).
  4. Kleim,Jeffrey Allan * . NEURAL MECHANISMS OF COMPENSATING FOR BRAIN DAMAGE. UTAustin (5/1/2011 - 9/25/2012).
  5. Kleim,Jeffrey Allan * . TrkB Receptors, Cortical Plasticity and Recovery After Stroke. AHA (4/2/2011 - 6/30/2012).
  6. Kleim,Jeffrey Allan * . BDNF Genotype Cortical Plasticity and Recovery From Stroke. HHS-NIH-NINDS (1/18/2011 - 2/28/2013).

* principal investigator

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Curriculum Vitae / Resume

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