ASU Help Center question mark icon

Michael Sierks

sierks@asu.edu

Professor
Sch Engr Matter Trnsprt Energy
Faculty
Mail Code: 6106

GWC 536 (Map)
(480)965-2828

Bio

Professor
Department of Chemical Engineering
Ira A. Fulton School of Engineering

Research interests include antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas include Ligand/receptor interactions, catalytic antibodies and enzyme mechanisms.

Expertise

Neurodegenerative Disease Protein Engineering Enymology

Education

1988, Ph.D. Chemical Eng, Iowa State University
1982, M.S. Chemical Eng, Colorado State
1978, B.S. Chemical Eng, Stanford University

Courses

Spring 2014

Courses Taught This Semester
Course Number Course Title
CHE 592 Research
CHE 593 Applied Project
CHE 595 Continuing Registration
CHE 599 Thesis
CHE 792 Research
CHE 795 Continuing Registration
CHE 799 Dissertation

Fall 2013

Courses Taught This Semester
Course Number Course Title
ASU 101-CHE The ASU Experience
CHE 475 Biochemical Engineering
CHE 592 Research
CHE 593 Applied Project
CHE 598 Special Topics
CHE 599 Thesis
CHE 792 Research

Summer 2013

Courses Taught This Semester
Course Number Course Title
CHE 590 Reading and Conference
CHE 792 Research
CHE 795 Continuing Registration

Spring 2013

Courses Taught This Semester
Course Number Course Title
CHE 592 Research
CHE 593 Applied Project
CHE 599 Thesis
CHE 792 Research
CHE 795 Continuing Registration
CHE 799 Dissertation

Fall 2012

Courses Taught This Semester
Course Number Course Title
ASU 101-CHE The ASU Experience
CHE 475 Biochemical Engineering
CHE 592 Research
CHE 593 Applied Project
CHE 598 Special Topics
CHE 792 Research

Summer 2012

Courses Taught This Semester
Course Number Course Title
CHE 592 Research
CHE 792 Research
CHE 795 Continuing Registration
CHE 799 Dissertation

Spring 2012

Courses Taught This Semester
Course Number Course Title
CHE 590 Reading and Conference
CHE 592 Research
CHE 593 Applied Project
CHE 792 Research
CHE 795 Continuing Registration
CHE 799 Dissertation

Fall 2011

Courses Taught This Semester
Course Number Course Title
ASU 101-CHE The ASU Experience
CHE 475 Biochemical Engineering
CHE 598 Special Topics

Fall 2010

Courses Taught This Semester
Course Number Course Title
CHE 342 Intro Applied Chem Thermodyn
CHE 475 Biochemical Engineering
CHE 504 Intro Applied Chem Thermodyn
CHE 598 Special Topics

Fall 2009

Courses Taught This Semester
Course Number Course Title
CHE 342 Intro Applied Chem Thermodyn
CHE 475 Biochemical Engineering
CHE 504 Intro Applied Chem Thermodyn

Research Activity Research Awards

  1. Sierks,Michael Richard * . Nanobodies selective for oligomeric Tau species isolated from AD brain. HHS-NIH-NIA (9/30/2013 - 6/30/2015).
  2. Petuskey,William T * , Bimonte-Nelson,Heather , Coon,David Wayne , Gonzalez,Graciela H , Hecht,Sidney Michael , Sierks,Michael Richard , Smith,Brian , . FY14: Arizona Alzheimer's Disease Consortium. AADC (7/1/2013 - 6/30/2014).
  3. Sierks,Michael Richard * . Development of nanobodies that target amyloid- oligomers for individual diagnosis in Alzheimers disease. Mayo Clinic, Fla (2/1/2013 - 1/31/2015).
  4. Sierks,Michael Richard * . Affinity Maturation of an Antibody Based Therapeutic Targeting Microglial Activation. ASU-Mayo Seed Grant (1/1/2013 - 12/31/2013).
  5. Sierks,Michael Richard * . Oligomeric Neuronal Protein Aggregates as Biomarkers for Traumatic Brain Injury (TBI) and Alzheimer Disease (AD). DOD-ARMY-USAMRMC (9/25/2012 - 9/24/2014).
  6. Sierks,Michael Richard * . Developing Diagnostic Nanobodies Against Aggregated TDP-43 Species. HHS-NIH-NIA (8/1/2012 - 7/31/2014).
  7. Gonzalez,Graciela H * Bimonte-Nelson,Heather Burleson,Mary Coon,David Wayne Mcclain,Darya Denise Sierks,Michael Richard . FY 13: Arizona Alzheimer's Disease Consortium. AADC (7/1/2012 - 6/30/2013).
  8. Sierks,Michael Richard * . Intracellular Tools to Study Specific Misfolded Protein Variants in Human Disease. HHS-NIH-NIA (8/1/2011 - 7/31/2014).
  9. Gonzalez,Graciela H * , Gonzalez,Graciela H * , Sierks,Michael Richard * , Burleson,Mary , Burleson,Mary , Coon,David Wayne , Coon,David Wayne , Mcclain,Darya Denise , Mcclain,Darya Denise , Sierks,Michael Richard , Sierks,Michael Richard , . C/S: Arizona Alzheimer's Disease Core Center. AADC (7/1/2011 - 6/30/2012).
  10. Sierks,Michael Richard * . Morphology specific anti-synuclein nanobodies as therapeutics for PD. MICHAEL J. FOX FDN. (11/1/2010 - 5/16/2013).
  11. Sierks,Michael Richard * Prasad,Shalini . Identifying and localizing toxic oligomeric a-syn with morphology specific nanobodies. MICHAEL J. FOX FDN. (11/1/2010 - 2/28/2012).
  12. Sierks,Michael Richard * . High Throughput Tau Oligomer Assay for Drug Screening for Alzheimer's Disease. OLIGOMERIX (8/1/2010 - 7/31/2012).
  13. Sierks,Michael Richard * . YR1: Intracellular Targeting and Clearance of Toxic Synuclein Aggregates. ABRC (7/1/2010 - 6/30/2012).
  14. Sierks,Michael Richard * . In vivo SPECT Imaging of synuclein aggregation with morphology specific antibody based ligands. MICHAEL J. FOX FDN. (5/1/2010 - 8/23/2011).
  15. Renaut,Rosemary Anne * Bimonte-Nelson,Heather Coon,David Wayne Gonzalez,Graciela H Marchant,Gary E Sierks,Michael Richard . AZ ASU Alzheimer's Research Center Project - 12. AADC (7/1/2009 - 6/30/2010).
  16. Sierks,Michael Richard * . In vivo SPECT Imaging of synuclein aggregation with morphology specific antibody based ligands. MICHAEL J. FOX FDN. (1/1/2009 - 3/31/2010).
  17. Sierks,Michael Richard * . Targeted Hydrolysis of B-amyloid with Engineered Antibody Fragments. ISOA (1/1/2009 - 12/31/2009).
  18. Renaut,Rosemary Anne * Bimonte-Nelson,Heather Coon,David Wayne Johnston,Stephen Albert Marchant,Gary E Sierks,Michael Richard Ye,Jieping . AZ ASU Alzheimer's Reserach Center Project- Year 11. AADC (7/1/2008 - 6/30/2009).
  19. Sierks,Michael Richard * . High Throughput Tau Oligomer Assay for Drug Screening for Alzheimer's Disease. OLIGOMERIX (6/16/2008 - 5/1/2009).
  20. Sierks,Michael Richard * . Conformation-specific Single-chain Antibodies as Neurodegeneration Research Tools. HHS-NIH-NINDS (4/1/2008 - 3/31/2011).
  21. Sierks,Michael Richard * . Intrabody Targeting of Toxic Huntington Aggregates. CHDI (2/1/2008 - 1/31/2009).
  22. Renaut,Rosemary Anne * Aiken,Leona S Bimonte-Nelson,Heather Coon,David Wayne Farin,Gerald E Johnston,Stephen Albert Sierks,Michael Richard . AZ ASU Alzheimer's Research Center Project - Year 10. AADC (7/1/2007 - 6/30/2008).
  23. Sierks,Michael Richard * . Morphology Specific Antibodies to Beta-Amyloid. BrightFocus (4/1/2007 - 3/31/2009).
  24. Arntzen,Charles * Jacobs,Bertram Lewis Leket-Mor,Tsafrir Shlomo Mason,Hugh S Sierks,Michael Richard . BiaCore Instrument Purchase. HHS-NIH (3/1/2007 - 2/28/2009).
  25. Sierks,Michael Richard * . Intracellular Targeting of Oligomeric a-Synuclein as a Potential Therapeutic for Parkinson's Disease. MICHAEL J. FOX FDN. (11/1/2006 - 10/31/2007).
  26. Sierks,Michael Richard * . Morphology Specific Antibodies for Treating Parkinson's - Year 3. ABRC (7/1/2006 - 6/30/2007).
  27. Alexander,Gene Evans * Bimonte-Nelson,Heather Coon,David Wayne Farin,Gerald E Johnston,Stephen Albert Renaut,Rosemary Anne Sierks,Michael Richard . AZ ASU Alzheimer's Research Center Project. AZ ADCC (7/1/2006 - 6/30/2007).
  28. Booksh,Karl S * Sierks,Michael Richard . Development of a Modular, Fiber Optic Surface Plasmon Resonance Sensor for Quantitation of Diagnostic Proteins for Healing of Burns and Wounds. NASA-NATL SPACE BIOMED RES INS (1/1/2006 - 1/31/2007).
  29. Sierks,Michael Richard * . Single Chain Antibody Binding Variable Domains (scFv) Development to Various Morphologies of Htt Aggregation. CHDI (10/1/2005 - 12/31/2006).
  30. Sierks,Michael Richard * . Translational Research on Abeta Metabolism, From Synthesis to Clearance. SUN HEALTH RESEARCH INST (9/1/2005 - 8/31/2008).
  31. Sierks,Michael Richard * . Morphology Specific Antibodies for Treating Parkinson's - Year 2. ABRC (7/1/2005 - 6/30/2006).
  32. Sierks,Michael Richard * . Development of an Early Diagnostic and Treatment for Alzheimer's Disease. MAYO CLINIC SCOTTSDALE (9/29/2004 - 12/31/2005).
  33. Booksh,Karl S * Khairallah,Philip A Nieman,Ronald A Sierks,Michael Richard . Fiber Optic Surface Plasmon Resonance Sensor for Protein Biomarkers. HHS-NIH-NIBIB (9/1/2004 - 6/30/2008).
  34. Sierks,Michael Richard * Lyubchenko,Yuri . Morphology Specific Antibodies for Treating Parkinson's. ABRC (7/1/2004 - 6/30/2005).
  35. Sierks,Michael Richard . Role of Protein-Lipid Bilayer Interactiontism in a-Synuclein Aggregation. HHS-NIH-NIA (5/1/2004 - 4/30/2007).
  36. Chang,Yung * Brophy,Colleen M Jacobs,Bertram Lewis Misra,Rajeev Pettit,George Robert Sierks,Michael Richard Zautra,Alex John . THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR (4/1/2004 - 3/31/2005).
  37. Sierks,Michael Richard * Lyubchenko,Yuri . Morphology Specific Antibodies as Potential Therapeutics. MICHAEL J. FOX FDN. (12/18/2003 - 12/31/2005).

* principal investigator

Your profile? You control what’s displayed. Customize your information.