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Michael Caplan

Michael.Caplan@asu.edu

Assoc Professor
Sch Biological & Hlth Sys Engr
Faculty
Mail Code: 9709

ISTB1 281M (Map)
(480)965-5144

Courses

Spring 2015

Courses Taught This Semester
Course Number Course Title
BME 331 Transport Phenomena for BME
BME 394 Special Topics
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 590 Reading and Conference
BME 593 Applied Project
KIN 499 Individualized Instruction

Fall 2014

Courses Taught This Semester
Course Number Course Title
ASU 101-BME The ASU Experience
BME 282 Biomedical Prod Dsgn & Dev II
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 593 Applied Project
CHE 592 Research
CHE 792 Research

Spring 2014

Courses Taught This Semester
Course Number Course Title
BME 331 Transport Phenomena for BME
BME 492 Honors Directed Study
BME 493 Honors Thesis
BME 593 Applied Project

Fall 2013

Courses Taught This Semester
Course Number Course Title
ASU 101-BME The ASU Experience
BME 282 Biomedical Prod Dsgn & Dev II
BME 593 Applied Project
CHE 592 Research
CHE 792 Research

Spring 2013

Courses Taught This Semester
Course Number Course Title
BME 331 Bioengr Transport Phenomena
BME 593 Applied Project

Fall 2012

Courses Taught This Semester
Course Number Course Title
BME 494 Special Topics
BME 593 Applied Project
BME 598 Special Topics
CHE 592 Research
CHE 792 Research

Summer 2012

Courses Taught This Semester
Course Number Course Title
CHE 231 IntroTransport Phenom I:Fluids

Spring 2012

Courses Taught This Semester
Course Number Course Title
BME 331 Bioengr Transport Phenomena
BME 593 Applied Project

Fall 2011

Courses Taught This Semester
Course Number Course Title
BME 598 Special Topics

Spring 2011

Courses Taught This Semester
Course Number Course Title
BME 331 Bioengr Transport Phenomena

Fall 2010

Courses Taught This Semester
Course Number Course Title
BME 499 Individualized Instruction
BME 598 Special Topics

Publications and Other Intellectual ContributionsGoogle Scholar

  1. Morgan B. Giers, Alex C. McLaren, Jonathan D. Placencia, David Frakes, Ryan McLemore, Michael R. Caplan. Spatiotemporal Quantification of Local Drug Delivery Using MRI. Computational and Mathematical Methods in Imaging (2013).

  2. Addie Hicks, Michael R. Caplan, Alyssa Panitch, James Sweeney. An Incubatable Direct Current Stimulation System for In Vitro Studies of Mammalian Cells. BioResearch Open Access (2012).

  3. Liping Xu, Jatinder S. Josan, Josef Vagner, Michael R. Caplan, Victor J. Hruby, Eugene A. Mash, Ronald M. Lynch, David L. Morse, and Robert J. Gillies. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proceedings of the National Academy of Sciences USA (2012).

  4. Morgan B. Giers, Chris S. Estes, Alex C. McLaren, Michael R. Caplan, Ryan McLemore. Jeannette Wilkins award: can locally delivered gadolinium be visualized on MRI? A pilot study. Clinical Orthopaedic Related Research (2012).

  5. Venkat Shankarraman, Grace Davis-Gorman, Jack G. Copeland, Michael R. Caplan and Paul F. McDonagh. Standardized Methods to Quantify Thrombogenicity of Blood-contacting Materials via Thromboelastography. Journal of Biomedical Materials Research – Part B: Applied Biomaterials (2012).

  6. Venkat Shankarraman, Grace Davis-Gorman, Paul F. McDonagh and Michael R. Caplan. Intracellular Signaling Controls Endothelial Cell Prostacyclin Secretion and Regulation of Blood Clotting Time. Journal of Biomedical Materials Research – Part A (2012).

  7. Bret G. Kelso, Jeremy B. Brower, Jerome H. Targovnik, Michael R. Caplan. Pyridoxine Restores Endothelial Cell Function in High Glucose. Metabolic Syndrome and Related Disorders (2011).

  8. Christine M. Pauken and Michael R. Caplan. Temporal differences in Erk1/2 activity distinguish among combinations of extracellular matrix components. Acta Biomaterialia (2011).

  9. Doris Hom Eng, Michael Caplan, Mark Preul, Alyssa Panitch. Hyaluronan scaffolds: a balance between backbone functionalization and bioactivity. Acta Biomaterialia (2010).

  10. Elena V. Rosca, Michael R. Caplan. Mathematical Modeling of Nanoparticle Targeting. Methods in Bioengineering: Nanoscale Bioengineering and Nanomedicine (2010).

  11. Jeremy Brower, Jerome Targovnik, Michael R. Caplan, Stephen P. Massia. High glucose-mediated loss of cell surface heparan sulfate proteoglycan impairs the endothelial shear stress response. Cell Motility and the Cytoskeleton (2010).

  12. Karen C. Butterfield, Michael R. Caplan, Alyssa Panitch. Identification and Sequence Composition Characterization of Chondroitin Sulfate-Binding Peptides through Peptide Array Screening. Biochemistry (2010).

  13. Karen Chao Butterfield, Aaron Conovaloff, Michael Caplan, Alyssa Panitch. Chondroitin sulfate-binding peptides block chondroitin 6-sulfate inhibition of cortical neurite growth. Neuroscience Letters (2010).

  14. Satterfield BC, Bartosiewicz M, West JA, Caplan MR. Surpassing specificity limits of nucleic acid probes via cooperativity. J Mol Diagn (2010).

  15. Venkat Shankarraman, Miti M. Shah and Michael R. Caplan. Substrates Elicit Different Patterns of Intracellular Signaling Which in Turn Cause Differences in Cell Adhesion. Cellular and Molecular Bioengineering (2010).

  16. Veronica Clavijo-Jordan, Michael R. Caplan, Kevin M. Bennett. Simplified Synthesis and Relaxometry of Magnetoferritin for Magnetic Resonance Imaging. Magnetic Resonance in Medicine (2010).

  17. Elena V. Rosca, Robert J. Gillies, Michael R. Caplan. Glioblastoma Targeting via Integrins is Concentration Dependent. Biotechnology & Bioengineering (2009).

  18. Jeremy Brower, Jerome Targovnik, Michael R. Caplan, Stephen P. Massia. Elevated Glucose Impairs the Endothelial Cell Response to Shear Stress. Cellular and Molecular Engineering (2009).

  19. Jill M. Stukel and Michael R. Caplan. Targeted Drug Delivery for Treatment and Imaging of Glioblastoma Multiforme. Expert Opinion in Drug Delivery (2009).

  20. Jill M. Stukel, Ronald Li, Heather Maynard, Michael R. Caplan. Two-step synthesis of multivalent cancer-targeting constructs. Biomacromolecules (2009).

  21. Michael R. Caplan, Miti M. Shah. Translating Biomaterial Properties to Intracellular Signaling. Cell Biochemistry and Biophysics (2009).

  22. Rosca EV, Gillies RJ, Caplan MR. Glioblastoma targeting via integrins is concentration dependent. Biotect & Bioeng (2009).

  23. Ryan McLemore, Stephanie A. Robb, Bae Hoon Lee, Michael R. Caplan, Brent L. Vernon. NIPAAm based Michael-Type addition reactions follow Second Order Rate Laws. Ann Biomed Eng (2009).

  24. Brent C. Satterfield, Michael R. Caplan, Jay A. A. West. Tentacle Probe Sandwich Assay on Porous Polymer Monolith Increases Sensitivity and Selectivity. Nucleic Acids Research (2008).

  25. Jill Stukel, Jason Parks, Michael R. Caplan, Stephen Helms-Tillery. Temporal and Spatial Control of Neural Effects Following Intracerebral Microinfusion. Journal of Drug Targeting (2008).

  26. Jill Stukel, Jeffrey J. Heys, Michael R. Caplan. Optimizing Delivery of Multivalent Targeting Constructs for Detection of Secondary Tumors. Annals of Biomedical Engineering (2008).

  27. Thomas A. Shewmake, Francisco J. Solis, Robert J. Gillies, Michael R. Caplan. Effects of Linker Properties on Multivalent Targeting. Biomacromolecules (2008).

  28. Brent C. Satterfield, David Kulesh, David Norwood, Leonard Wasieloski, Jay A. A. West, Michael R. Caplan. Tentacle Probes™: differentiation of difficult single nucleotide polymorphisms and deletions by presence or absence of a signal in real time PCR. Clinical Chemistry (2007).

  29. Brent C. Satterfield, Jay A. A. West, and Michael R. Caplan. Tentacle probes: eliminating false positives without sacrificing sensitivity. Nucleic Acids Research (2007).

  30. Brent C. Satterfield, Seth Stern, Michael R. Caplan, Kyle W. Hukari, and Jay A. A. West. Microfluidic purification and preconcentration of mRNA by flow-through polymeric monolith. Analytical Chemistry (2007).

  31. Christopher L Klaver and Michael R. Caplan. Bioactive surface for neural electrodes: decreasing astrocyte proliferation via transforming growth factor-beta1. J Biomed Mater Res A (2007).

  32. Elena V. Rosca, Jill Stukel, Robert J. Gillies, Joseph Vagner, Michael R. Caplan. Specificity and Mobility of Polymeric, Multivalent Constructs for Cellular Targeting. Biomacromolecules (2007).

  33. Satterfield, Brent C., Jay A. A. West, and Michael R. Caplan. When Flow Rates Matter: a dimensionless analysis of the effect of heat energy convection on microfluidic chip power consumption and temperature homogeneity. Journal of Undergraduate Research In Bioengineering (JURIBE) (2007).

  34. Michael R. Caplan and Elena V. Rosca. Targeting drugs to combinations of receptors: a modeling analysis of potential specificity. Annals of Biomedical Engineering (2005).

  35. Caplan, Michael R. and Harold P. Erickson. Apparent Cooperative Assembly of the Bacterial Cell-Division Protein FtsZ Determined by Isothermal Titration Calorimetry. Journal of Biological Chemistry (2003).

  36. Michael Caplan, Douglas Lauffenburger. Nature's Complex Copolymers: Engineering Design of Oligopeptide Materials. Industrial & Engineering Chemistry Research (2002).

  37. Michael Caplan, Elissa Schwartzfarb, Shuguang Zhang, Roger Kamm, Douglas Lauffenburger. Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence. Biomaterials (2002).

  38. Michael Caplan, Elissa Schwartzfarb, Shuguang Zhang, Roger Kamm, Douglas Lauffenburger. Effects of Systematic Variation of Amino Acid Sequence on the Mechanical Properties of a Self-assembling, Oligopeptide Biomaterial. J Biomaterial Science - Polymer Edition (2002).

  39. Caplan, Michael R., Peter N. Moore, Shuguang Zhang, Roger D. Kamm, Douglas A. Lauffenburger. Self-assembly of a ß sheet protein is governed by relief of electrostatic repulsion relative to van der Waals attraction. Biomacromolecules (2000).

  40. Michael Caplan, Chung-Yuan Chiang, Douglas Lloyd, Larry Yen. Formation of microporous Teflon® PFA membranes via thermally induced phase separation. Journal of Membrane Science (1997).

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Research Activity Research Awards

  1. Caplan,Michael Ryckman * , Vernon,Brent , . Understanding Antimicrobial and Fluid Distribution in Orthopaedic Wounds for the Management of Infection and Trauma. Banner Good Sam (7/1/2011 - 6/30/2013).
  2. Caplan,Michael Ryckman * Vernon,Brent . Understanding Antimicrobial and Fluid Distribution in Orthopaedic Wounds for the Management of Infection and Trauma. Banner Good Sam (7/1/2010 - 6/30/2013).
  3. Caplan,Michael Ryckman * . Systems Biology in Response to Biomaterials. ABRC (7/1/2009 - 6/30/2011).
  4. Caplan,Michael Ryckman * . Multimeric Ligands for Targeting Melanoma. HLMCCRI (8/8/2008 - 5/31/2010).
  5. Caplan,Michael Ryckman * . Intracellular Signaling in Response to Biomaterials - Dummy Parent. AMER HEART ASSOC, NTNL CNTR (7/1/2008 - 6/30/2012).
  6. Caplan,Michael Ryckman * . Systems Biology in Response to Biomaterials. ABRC (7/1/2008 - 6/30/2009).
  7. Caplan,Michael Ryckman * . Intracellular Signaling in Response to Biomaterials. AMER HEART ASSOC, NTNL CNTR (7/1/2008 - 6/30/2009).
  8. Caplan,Michael Ryckman * . Rational Design of Bioactive Materials via Substrate Composition and Compliance. HHS-NIH-NIBIB (9/1/2006 - 8/31/2009).
  9. Caplan,Michael Ryckman * . Elucidation of Protein-Polysaccharide Interactions for Vascular Tissue Engineering. AMER HEART ASSN (7/1/2006 - 6/30/2008).
  10. Caplan,Michael Ryckman * . Multimeric Ligands for Targeting Cancer for Imaging and Therapy. UNIV OF AZ (7/1/2006 - 6/30/2009).
  11. Caplan,Michael Ryckman * . Multivalent Ligands for Targeting Invasive Tumor Cells. HHS-NIH-NINDS (4/1/2005 - 3/31/2008).
  12. Caplan,Michael Ryckman * . SYSTEMATIC DESIGN OF BIOMIMETIC BASEMENT MEMBRANES. HHS-NIH-NIDCR (9/1/2003 - 6/30/2008).

* principal investigator

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Service

  1. ABET, Program Evaluator (2012 - present)
  2. Institutional Biosafety Committee, Vice-Chair (2007 - present)
  3. American Association of Engineering Education, Member (2005 - present)
  4. Biomedical Engineering Society, Member (1999 - present)
  5. Society For Biomaterials, Member (1997 - present)

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