ASU Help Center question mark icon

Lawrence Mandarino

Bio

Director, Center for Metabolic Biology
Professor and Chair, Department of Kinesiology, College of Liberal Arts and Sciences

Professor of Medicine, Mayo Clinic Arizona

Office ISTB1-481H
Phone: 480-965-2473
Fax: 480-727-6183
[email protected]

Bio

Lawrence Mandarino arrived at ASU in December, 2004, to become the Chair of Kinesiology and the Director of the Center for Metabolic Biology, an interdisciplinary Center designed to bring together basic and clinical scientists to understand the mechanisms responsible for insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Before coming to ASU, Dr. Mandarino spent more than 12 years at the University of Texas Health Science Center at San Antonio in the Departments of Medicine, Biochemistry, and Physiology. He has held faculty appointments at the University of Pittsburgh and the University of California, San Diego, after performing a postdoctoral fellowship in Endocrinology at the Mayo Clinic.

Research

Research in the Mandarino laboratory focuses on the molecular mechanisms responsible for insulin resistance in human skeletal muscle. Of particular interest are the roles of mitochondrial dysfunction and the regulation of IRS-1 (Insulin Receptor Substrate-1) function. Experimental systems employed to study these issues include a wide variety of appropriate techniques, ranging from in vivo methods to assess human metabolic events, such as the euglycemic hyperinsulinemic clamp, muscle biopsies, arterial catheterizations, and use of stable isotopes to assess metabolic rates to cell culture and molecular biology techniques for addressing questions of insulin signaling. The Proteomics Laboratory, with modern and highly powerful mass spectrometers that can be used for a variety of proteomics techniques, provides especially critical ability to analyze protein phosphorylation. Dr. Mandarino's research has been supported by the National Institutes of Health for over 20 years, and he has over 100 publications in peer-reviewed journals.

Selected Publications

1. Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub ST, Mandarino LJ. Identification of Insulin Receptor Substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: Regulatory role of serine 1223. Endocrinology 146: 4410-4416, 2005.

2. Yi Z, Luo M, Carroll CA, Weintraub ST, Mandarino LJ. Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high performance liquid chromatography-electrospray ionization tandem mass spectrometry. Analytical Chemistry 77: 5693-5699, 2005.

3. Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, Defronzo RA. Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients. Diabetes 54: 3148-3153, 2005.

4. Sriwijitkamol Piradee, Ivy John L, Christ-Roberts Christine, DeFronzo Ralph A, J Mandarino Lawrence, and Musi Nicolas. LKB1-AMPK Signaling in Muscle from Obese Insulin Resistant Zucker Rats and Effects of Training. Am. J. Physiol, Dec 2005.

5. Sriwijitkamol A, Christ-Roberts C, Berria R, Eagan P, Pratipanawatr T, DeFronzo RA, Mandarino LJ, Musi N. Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training. Diabetes. 2006 Mar;55(3):760-7.

6. Yi Z, Luo M, Mandarino LJ, Reyna SM, Carroll CA, Weintraub ST. Quantification of Phosphorylation of Insulin Receptor Substrate-1 by HPLC-ESI-MS/MS. J Am Soc Mass Spectrom. 2006 Apr;17(4):562-7.

Courses

Summer 2015

Courses Taught This Semester
Course Number Course Title
BDE 792 Research

Spring 2015

Courses Taught This Semester
Course Number Course Title
BDE 792 Research

Fall 2014

Courses Taught This Semester
Course Number Course Title
BDE 792 Research

Summer 2014

Courses Taught This Semester
Course Number Course Title
BDE 792 Research

Spring 2014

Courses Taught This Semester
Course Number Course Title
BDE 792 Research
BIO 191 First-Year Seminar

Fall 2013

Courses Taught This Semester
Course Number Course Title
BDE 792 Research

Spring 2013

Courses Taught This Semester
Course Number Course Title
BIO 191 First-Year Seminar

Fall 2012

Courses Taught This Semester
Course Number Course Title
BIO 495 Undergraduate Research

Spring 2012

Courses Taught This Semester
Course Number Course Title
BIO 493 Honors Thesis
BIO 495 Undergraduate Research

Fall 2011

Courses Taught This Semester
Course Number Course Title
BIO 492 Honors Directed Study
BIO 495 Undergraduate Research

Fall 2010

Courses Taught This Semester
Course Number Course Title
BIO 492 Honors Directed Study
KIN 191 First-Year Seminar

Publications and Other Intellectual ContributionsGoogle Scholar

  1. Boyle KE, Hwang H, Janssen RC, DeVente JM, Barbour LA, Hernandez TL, Mandarino LJ, Lappas M, Friedman JE.. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle.. PLoS One (2014).

  2. DeMenna J, Puppala S, Chittoor G, Schneider J, Kim JY, Shaibi GQ, Mandarino LJ, Duggirala R, Coletta DK.. Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona Insulin Resistance registry: a focus on Mexican American families in the Southwest.. Hum Hered. (2014).

  3. Mielke C, Lefort N, McLean CG, Cordova JM, Langlais PR, Bordner AJ, Te JA, Ozkan SB, Willis WT, Mandarino LJ.. Adenine nucleotide translocase is acetylated in vivo in human muscle: Modeling predicts a decreased ADP affinity and altered control of oxidative phosphorylation.. Biochemistry (2014).

  4. Mielke CJ, Mandarino LJ, Dinu V.. AMASS: a database for investigating protein structures.. Bioinformatics (2014).

  5. Miranda DN, Coletta DK, Mandarino LJ, Shaibi GQ. (Silver Spring).. Increases in insulin sensitivity among obese youth are associated with gene expression changes in whole blood.. Obesity (2014).

  6. Nair KS, Abel ED, Adler SG, Dyck PJ, Gardner TW, Haskins KM, Hotamisligil G, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A.. Time to look back and to look forward.. Diabetes. (2014).

  7. Xie X, Langlais P, Zhang X, Heckmann BL, Saarinen AM, Mandarino LJ, Liu J.. Identification of a novel phosphorylation site in adipose triglyceride lipase as a regulator of lipid droplet localization.. Am J Physiol Endocrinol Metab. (2014).

  8. Beeman SC, Mandarino LJ, Georges JF, Bennett KM. Cationized ferritin as a magnetic resonance imaging probe to detect microstructural changes in a rat model of non-alcoholic steatohepatitis.. Magnetic Resonance in Medicine (2013).

  9. Chakkera, HA, Mandarino, LJ. Calcineurin Inhibition and New-Onset Diabetes Mellitus After Transplantation. Transplantation (2013).

  10. Puga, GM, Meyer, C, Mandarino, LJ, Katsanos, CS. Increased plasma availability of L-arginine in the postprandial period decreases the postprandial lipemia in older adults. Nutrition (2013).

  11. Shaibi, GQ, Coletta, DK, Vital, V, Mandarino, LJ. The Design and Conduct of a Community-Based Registry and Biorepository: A Focus on Cardiometabolic Health in Latinos. CLINICAL AND TRANSLATIONAL SCIENCE (2013).

  12. Tangen, SE, Tsinajinnie, D, Nuñez, M, Shaibi, GQ, Mandarino, LJ, Coletta, DK. Whole blood gene expression profiles in insulin resistant Latinos with the metabolic syndrome. PLOS One (2013).

  13. Chao A, Zhang X, Ma D, Langlais P, Luo M, Mandarino LJ, Zingsheim M, Pham K, Dillon J, Yi Z. Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin.. J. Proteomics (2012).

  14. Kim JY, Coletta DK, Mandarino LJ, Shaibi GQ. Glucose response curve and type 2 diabetes risk in Latino adolescents.. Diabetes Care (2012).

  15. Langlais P, Dillon JL, Mengos A, Baluch DP, Ardebili R, Miranda DN, Xie X, Heckmann BL, Liu J, Mandarino LJ. Identification of a Role for CLASP2 in Insulin Action. J Biol Chem (2012).

  16. Luo M, Mengos AE, Stubblefield TM, Mandarino LJ. High Fat Diet-Induced Changes in Hepatic Protein Abundance in Mice. Journal of Proteomics and Bioinformatics (2012).

  17. Puga GM, Meyer C, Mandarino LJ, Katsanos CS. Postprandial spillover of dietary lipid into plasma is increased with moderate amounts of ingested fat and is inversely related to adiposity in healthy older men. J. Nutrition (2012).

  18. Chakkera HA, Mandarino LJ. Calcineurin Inhibition and New-Onset Diabetes Mellitus After Transplantation. Transplantation (2012).

  19. Everman S, Yi Z, Langlais P, Mandarino LJ, Luo M, Roberts C, Katsanos CS.. Reproducibility of an HPLC-ESI-MS/MS method for the measurement of stable-isotope enrichment of in vivo-labeled muscle ATP synthase beta subunit.. PLoS One. (2011).

  20. Geetha T, Langlais P, Luo M, Mapes R, Lefort N, Chen SC, Mandarino LJ, Yi Z.. Label-free proteomic identification of endogenous, insulin-stimulated interaction partners of insulin receptor substrate-1.. J Am Soc Mass Spectrom. (2011).

  21. Ghosh S, Lertwattanarak R, Lefort N, Molina-Carrion M, Joya-Galeana J, Bowen BP, Garduno-Garcia Jde J, Abdul-Ghani M, Richardson A, DeFronzo RA, Mandarino L, Van Remmen H, Musi N.. Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance. Diabetes (2011).

  22. Holmes RM, Yi Z, De Filippis E, Berria R, Shahani S, Sathyanarayana P, Sherman V, Fujiwara K, Meyer C, Christ-Roberts C, Hwang H, Finlayson J, Dong LQ, Mandarino LJ, Bajaj M.. Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.. Diabetologia (2011).

  23. Langlais P, Yi Z, Finlayson J, Luo M, Mapes R, De Filippis E, Meyer C, Plummer E, Tongchinsub P, Mattern M, Mandarino LJ.. Global IRS-1 phosphorylation analysis in insulin resistance.. Diabetologia (2011).

  24. Langlais P, Yi Z, Mandarino LJ.. The identification of raptor as a substrate for p44/42 MAPK.. Endocrinology (2011).

  25. Puga GM, Meyer C, Everman S, Mandarino LJ, Katsanos CS.. Postprandial lipemia in the elderly involves increased incorporation of ingested fat in plasma free fatty acids and small (Sf 20-400) triglyceride-rich lipoproteins.. Am J Physiol Endocrinol Metab. (2011).

  26. Coletta DK, Mandarino LJ.. Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria.. Am J Physiol Endocrinol Metab. (2011).

  27. Katsanos CS, Mandarino LJ.. Protein metabolism in human obesity: a shift in focus from whole-body to skeletal muscle.. Obesity (2011).

  28. 120. Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Højlund K, Yi Z, Mandarino LJ.. Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle.. Diabetes (2010).

  29. Civitarese AE, MacLean PS, Carling S, Kerr-Bayles L, McMillan RP, Pierce A, Becker TC, Moro C, Finlayson J, Lefort N, Newgard CB, Mandarino L, Cefalu W, Walder K, Collier GR, Hulver MW, Smith SR, Ravussin E.. Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL. Cell Metabolism (2010).

  30. Højlund K, Yi Z, Lefort N, Langlais P, Bowen B, Levin K, Beck-Nielsen H, Mandarino LJ.. Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insultin-resistant muscle.. Diabetologia (2010).

  31. Kashyap SR, Roman LJ, Mandarino L, DeFronzo R, Bajaj M.. Hypoadiponectinemia is closely associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.. Metab Syndr Relat Disord. (2010).

  32. Kashyap SR, Roman LJ, Mandarino L, DeFronzo R, Bajaj M.. Hypoadiponectinemia is closely associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.. Metab Syndr Relat Disord. (2010).

  33. Langlais P, Mandarino LJ, Yi Z.. Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS.. J Am Soc Mass Spectromery (2010).

  34. Xie X, Yi Z, Bowen B, Wolf C, Flynn CR, Sinha S, Mandarino LJ, Meyer C.. Characterization of the Human Adipocyte Proteome and Reproducibility of Protein Abundance by One-Dimensional Gel Electrophoresis and HPLC-ESI-MS/MS.. Journal of Proteome Research (2010).

  35. Hojlund K, Yi Z, Lefort N, Langlais P, Bowen B, Levin K, Beck-Nielsen H, Mandarino LJ. Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle. Diabetologia (2009).

  36. Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Hojlund K, Yi Z, Mandarino LJ.. Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes (2009).

  37. Coletta DK. Balas B. Chavez AO. Baig M. Abdul-Ghani M. Kashyap SR. Folli F. Tripathy D. Mandarino LJ. Cornell JE. Defronzo RA. Jenkinson CP. Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo. American Journal of Physiology - Endocrinology & Metabolism (2008).

  38. De Filippis E. Alvarez G. Berria R. Cusi K. Everman S. Meyer C. Mandarino LJ.. Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise.. American Journal of Physiology - Endocrinology & Metabolism. (2008).

  39. Hojlund K. Yi Z. Hwang H. Bowen B. Lefort N. Flynn CR. Langlais P. Weintraub ST. Mandarino LJ.. Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.. Molecular & Cellular Proteomics. (2008).

  40. Yi Z. Bowen BP. Hwang H. Jenkinson CP. Coletta DK. Lefort N. Bajaj M. Kashyap S. Berria R. De Filippis EA. Mandarino LJ.. Global relationship between the proteome and transcriptome of human skeletal muscle.. Journal of Proteome Research. (2008).

Your profile? Go to FAR to control which information is displayed.

Presentations

  1. ELIZABETH A. JACOBSEN, JAMES J. LEE, KATIE R. ZELLNER, KARL KAIYALA, NANCY A. LEE, ELENA A. DE FILIPPIS, LAWRENCE J. MANDARINO Eosinophils Maintain Hepatic Insulin Sensitivity. American Diabetes Association Scientific Sessions. (Jun 2014).
  2. GABRIEL Q. SHAIBI, IFTIKHAR J. KULLO, ANGELA K. DALENBERG, DAWN K. COLETTA, LAWRENCE J. MANDARINO Osteocalcin and Type 2 Diabetes Risk across the Lifespan. American Diabetes Association Scientific Sessions. (Jun 2014).
  3. SAMANTHA E. TANGEN, LATOYA E. CAMPBELL, MARGARET K. LINAN, LORI R. ROUST, VALENTIN DINU, LAWRENCE J. MANDARINO, DAWN K. COLETTA Next Generation Sequencing Methylation Profiling and Whole Human Genome Microarray Analysis in Skeletal Muscle from Lean and Obese Subjects. American Diabetes Association Scientific Sessions. (Jun 2014).
  4. LAWRENCE J. MANDARINO, DAWN K. COLETTA, CARRIE G. SHAROFF, HARINI CHAKKERA Immune Suppression with Tacrolimus Does Not Inhibit Skeletal Muscle Gene Response to Exercise After Kidney Transplant. American Diabetes Association Scientific Sessions. (Jun 2014).
  5. XITAO XIE, ZHENGPING YI, SANDEEP SINHA, BEN BOWEN, PAUL LANGLAIS, LAWRENCE J. MANDARINO, CHRISTIAN MEYER Proteomics Analysis of Subcutaneous Adipocytes Reveals Novel Abnormalities in Human Insulin Resistance. American Diabetes Association Scientific Sessions. (Jun 2014).
  6. LAWRENCE J. MANDARINO, DAWN K. COLETTA, CARRIE G. MCLEAN, JEANINE M. CORDOVA, JEAN FINLAYSON, PAUL R. LANGLAIS Acute Exercise Activates a Metabolic Regulatory Network in Skeletal Muscle Involving Micro RNAs miR-378a and miR-30 in Humans. American Diabetes Association Scientific Sessions. (Jun 2013).
  7. KYUBEOM OH, NATALY P. PODOLNIKOVA, LAWRENCE J. MANDARINO, TATIANA P. UGAROVA Weight Gain and Changes in the Polarization of Fat Macrophages Towards the M1-Like Pro-Inflammatory Phenotype in Integrin Mac-1 (CD11b/CD18) Deficient Mice. American Diabetes Association Scientific Sessions. (Jun 2013).
  8. MOULUN LUO, APRIL E. MENGOS, TIANNA M. STUBBLEFIELD, PAUL R. LANGLAIS, WAYNE T. WILLIS, LAWRENCE J. MANDARINO Clustered Mitochondria Phenotype (Clu)-1 and Lipolysis-Stimulated Lipoprotein Receptor (LSR) Integrate Triglyceride (TG) Uptake and Mitochondrial Content in Liver. American Diabetes Association Scientific Sessions. (Jun 2013).
  9. PAUL R. LANGLAIS, JAMES L. DILLON, APRIL E. MENGOS, DEBRA P. BALUCH, RANNA ARDEBILI, DANIELLE N. MIRANDA, XITAO XIE, BRADLEE L. HECKMANN, JUN LIU, LAWRENCE J. MANDARINO Identification of a Role for CLASP2 in Insulin Action. American Diabetes Association Scientific Sessions. (Jun 2013).
  10. CLINTON MIELKE, BANU OZKAN, ANDREW BORDNER, JEREZ TE, WAYNE T. WILLIS, LAWRENCE J. MANDARINO Molecular Modeling Reveals Acetylation of Adenine Nucleotide Translocase (ANT) 1 Regulates Affinity for ADP. American Diabetes Association Scientific Sessions. (Jun 2013).
  11. Shaibi GQ, Hackett K, Monge A, Mandarino LJ, et al. HbA1c HbA1c accurately tracks glucose response during an OGTT among healthy, prediabetic and diabetic volunteers.. North Amer Assoc. for the study of obesity. (Oct 2011).
  12. Katsanos CS, Puga G, Everman S, Mandarino LJ, et al. Effects of fat meal ingestion on lipid-associated metabolic responses with aging.. North Amer Assoc. for the study of obesity. (Oct 2011).
  13. Natalie Lefort, Carrie G. Sharoff, Sarah Kuzmiak, Zhengping Yi, Paul Langlais , Jeanine Cordova, Clinton Mielke, Sefika Ozkan, Harini Chakkera, Wayne T. Willis, Lawrence J. Mandarino Dysregulation of acetylation of mitochondrial proteins after exercise in insulin resistance.. American Diabetes Association Scientific Sessions. (Jun 2011).
  14. Dawn K. Coletta, Darwin Tsinajinnie, Martha Nunez, Veronica Vital, Paul Langlais, Natalie Simard, Carrie Sharoff, Gabriel Q. Shaibi, Lawrence J. Mandarino Epigenetic mapping of insulin resistance in humans. American Diabetes Association Scientific Sessions. (Jun 2011).
  15. Cordova JM, Sharoff C, Tsinajinnie D, Chakerra H, Luo M, Langlais P, Mandarino LJ NFATc1 Activity in Human Insulin Resistant Skeletal Muscle. american Diabetes Association Scientific Sessions. (Jun 2011).
  16. Mandarino, L Proteomic Analysis in Isulin Resistant Muscle - Mitochondria and ROS. american Diabetes Association Scientific Sessions. (Jun 2011).
  17. Geetha T, Hojlund K, Zingsheim M, Mandarino L, et al. Novel tyrosine phosphorylation sites in skeletal muscle identified by HPLC-ESI-MS/MS.. Am Diabetes Assoc Scientific Sessions. (Jun 2010).
  18. Shahani S, Sathyanarayana P, Sherman V, Mandarino L, et al. Paradoxical decrease in skeletal muscle APPL1 expression following weight loss in obese humans.. American Diabetes Association Scientific Sessions. (Jun 2010).
  19. Xie XT, Yi ZP, Bowen B, Mandarino L, et al. Characterization of the human adipocyte proteome and protein quantification by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.. American Diabetes Association Scientific Sessions. (Jun 2010).
  20. Luo ML, Yi ZP, Langlais P, Mandarino LJ, et al. Liprin beta-1 decreases insulini receptor tyrosine phosphorylation by association with LAR-PTP.. American Diabetes Association Scientific Sessions. (Jun 2010).
  21. Langlais P, Yi ZP, Mandarino LJ. The identification of raptor as a substrate for p44/42 MAPK.. American Diabetes Association Scientific Sessions. (Jun 2010).
  22. Everman SR, Mandarino LJ, Puga GM, et al. Branched chain amino acid inhibition of insulin-mediated whole-body glucose disposal is not reversed by increased plasma insulin concentration.. American Diabetes Association Scientific Sessions. (Jun 2010).
  23. Coletta DK, Bowen B, Tsinajinnie D, Mandarino LJ, et al. Role of adiponectin receptor 2 rs929434: Association with dyslipidemia in Latinos from the Arizona insulin resistance registry.. American Diabetes Association Scientific Sessions. (Jun 2010).
  24. Geetha T, Langlais P, Lou ML, Mandarino LJ, et al. Protein phosphatase 1 regulatory subunit 12A (PPP1R12A), a new family member in the IRS-1 signaling complex.. American Diabetes Association Scientific Sessions. (Jun 2010).
  25. Langlais P, Yi ZP, Finlayson J, Mandarino LJ, et al. Characterization of IRS-1 phosphorylation in type 2 diabetes. Diabetes. American Diabetes Association Scientific Sessions. (Jun 2010).
  26. Boyle KE, Hwang H, Devente JE, Mandarino LJ, et al. Quantitative proteomic profile in skeletal muscle from women with gestational diabetes reveals potential for reduced mitochondrial function.. American Diabetes Association Scientific Sessions. (Jun 2010).
  27. Puga, G; Meyer, C; Mandarino, L; et al. Oxidation of Ingested Fat and Plasma Triacylglyceride Concentration in Elderly: A Dose-Response Study. North American Association for the Study of Obesity. (Nov 2009).
  28. Yi, ZP; Luo, ML; Mapes, R; Mandarino, L, et al. Identification of Novel IRS-1 Interacting Partners by HPLC-ESI-MS/MS. American Diabetes Association Scientific Sessions. (Jun 2009).
  29. Luo, ML; Yi, ZP; Langlais, PR; Mandarino, LJ et al Identification of Lamin A/C as an Insulin-Responsive Akt Substrate. American Diabetes Association Scientific Sessions. (Jun 2009).
  30. Mandarino, Lawrence Phosphorylation analysis of IRS-1 by Mass Spectrometry. Samuel Barshop Conference on Aging, Bandera Texas. (Oct 2007).
  31. Bajaj, M, Suraamornkul, S, Finlayson, J, De Filippis, E, Medina-Navarro, R, Defronzo, R, Mandarino, Lawrence Alteration in insulin sensitivity is associated with extracellular matrix remodeling in muscle of insulin resistant subjects. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  32. De Filippis, E, Alvarez, G, Berria, R, Meyer, C, Mandarino, Lawrence Delayed response to exercise (EX) of nuclear encoded mitochondrial gene expression in insulin resistant human muscle. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  33. Fujiwara, K, De Filippis, E, Berria, R, Meyer, C, Meyer, A, Finlayson, J, Medina-Navarro, R, Mandarino, Lawrence Pioglitazone (Pio) improves insulin sensitivity associated with decreased myocellular fatty acyl coenzyme A (FA-CoA) and increased PPAR-gamma coactivator (PGC)-1 expression in type 2 diabetes (T2DM). American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  34. Luo, M, Langlais, P, Yi, Z, Mandarino, Lawrence Interplay between phosphorylation of serines 629 and 636 in regulation of insulin receptor substrate (IRS)-1 function. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  35. Makdissi, A, Ioachimescu, A, Mandarino, Lawrence, Hazen, S, Kashyap, S Free fatty acids-induced insulin resistance in healthy subjects uncouples nitric oxide synthase pathway via arginine deficiency. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  36. Mandarino, Lawrence Phosphorylation of IRS-1. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  37. Medina-Navarro, R, Suraamornkul, S, Finlayson, J, De Filippis, E, Defronzo, R, Mandarino, Lawrence, Bajaj, M Decrease in plasma free fatty acids (FFA) improves insulin sensitivity and decreases intramyocellular fatty acyl coenzyme A in insulin resistant subjects. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  38. Miyazaki, Y, Mandarino, Lawrence, Defronzo, R Rosiglitazone improves insulin receptor signaling and peripheral insulin resistance in association with increased adiponectin level in type 2 diabetic patients. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  39. Richardson, D, Balas, B, Baig, M, Abdul-Ghani, M, Kashyap, S, Mandarino, Lawrence, Defronzo, R, Cornell, J, Jenkinson, C Insulin acutely regulates gene expression in human skeletal muscle in vivo. American Diabetes Association Annual Scientific Sessions. (Jun 2006).
  40. Sriwijitkamol, A, Ivy, J, Christ-Roberts, C, Defronzo, R, Mandarino, Lawrence, Musi, N Reduced muscle I kappa B expression and insulin resistance in obese Zucker rats: Effect of training. American Diabetes Association Annual Scientific Sessions. (Jun 2006).

Your profile? You control what’s displayed. Customize your information.

Research Activity Research Awards

  1. Mandarino,Lawrence * , Mandarino,Lawrence * , Coletta,Dawn , Willis,Wayne Tyrus , Willis,Wayne Tyrus , . PGC-1 Muscle Mitochondrial Dysfunction in Diabetes. HHS-NIH-NIDDK (1/15/2014 - 12/31/2018).
  2. Mandarino,Lawrence * . Arizona Insulin Resistance Registry Phone Recruitment. MAYO CLINIC SCOTTSDALE (12/1/2012 - 12/31/2014).
  3. Katsanos,Christos * , Langlais,Paul , Mandarino,Lawrence , Willis,Wayne Tyrus , . Regulation of Muscle ATP Synthase Beta Subunit Metabolism in Obesity. HHS-NIH-NIDDK (9/4/2012 - 6/30/2016).
  4. Coletta,Dawn * Dinu,Valentin Mandarino,Lawrence Meyer,Christian . Epigenetics and the Origin of Muscle Insulin Resistance in Humans. HHS-NIH-NIDDK (8/6/2012 - 7/31/2017).
  5. Katsanos,Christos * Mandarino,Lawrence . Regulation of the Plasma Triglyceride Extraction in Muscle in Insulin Resistance. AMER DIABETES ASSN (7/1/2012 - 6/30/2015).
  6. Mandarino,Lawrence * , Mandarino,Lawrence * , Langlais,Paul , Magee,Dewey Mitchell , Ozkan,Sefika Banu , Willis,Wayne Tyrus , Willis,Wayne Tyrus , . Molecular Regulation of Muscle Glucose Metabolism in Man. HHS-NIH-NIDDK (2/1/2012 - 1/31/2017).
  7. Mandarino,Lawrence * . Selenium Colorectal Cancer Chemoprevention Trials. UNIV OF AZ CANCER CNTR (8/1/2011 - 7/31/2015).
  8. Mandarino,Lawrence * Mandarino,Lawrence * . ASU-Mayo CMVB Collaborative Agreement. MAYO CLINIC SCOTTSDALE (5/17/2010 - 6/30/2015).
  9. Mandarino,Lawrence * Brophy,Colleen M Meyer,Christian Willis,Wayne Tyrus Yi,Zhengping . PGC-1 & Mitochondrial Dysfunction in Diabetes. HHS-NIH-NIDDK (12/31/2009 - 11/30/2010).
  10. Mandarino,Lawrence * . ASU-Mayo CMVB Collaborative Agreement: Personnel. MAYO CLINIC SCOTTSDALE (12/1/2009 - 6/30/2014).
  11. Meyer,Christian * Meyer,Christian * Bowen,Benjamin P Katsanos,Christos Katsanos,Christos Mandarino,Lawrence Mandarino,Lawrence Willis,Wayne Tyrus Yi,Zhengping Yi,Zhengping . Adiopcyte Mitochondrial Dysfunction in Insulin Resistance. HHS-NIH-NIDDK (8/5/2009 - 7/30/2011).
  12. Mandarino,Lawrence * . Metabolic Syndrome Diseases. MAYO CLINIC SCOTTSDALE (6/8/2009 - 6/30/2011).
  13. Yi,Zhengping * Yi,Zhengping * Bowen,Benjamin P Chen,Shu-Chuan Mandarino,Lawrence Mandarino,Lawrence Meyer,Christian Meyer,Christian Ye,Jieping . Human Skeletal Muscle Proteome and Phosphoproteome in Obesity and Type 2 Diabetes (yr 2). HHS-NIH-NIDDK (2/1/2009 - 1/31/2011).
  14. Meyer,Christian * Meyer,Christian * Bowen,Benjamin P Mandarino,Lawrence Mandarino,Lawrence Willis,Wayne Tyrus Yi,Zhengping Yi,Zhengping . Role of adipocyte mitochondria in human insulin resistance. AMER DIABETES ASSN (1/1/2009 - 12/31/2011).
  15. Mandarino,Lawrence * . Center for Metabolic Biology Distinguished Lecture Series. Roche Lab (12/30/2008 - 2/28/2009).
  16. Greenes,Robert * Mandarino,Lawrence . BMI - AHCCCS Interagency Agreement: Research Liaison and Community Engagement - Task Three. AHCCCS (7/21/2008 - 12/31/2009).
  17. Mandarino,Lawrence * Mandarino,Lawrence * Brophy,Colleen M Meyer,Christian Willis,Wayne Tyrus Yi,Zhengping . PGC-1 Muscle Mitochondrial Dysfunction in Diabetes. HHS-NIH-NIDDK (7/5/2008 - 1/14/2014).
  18. Mandarino,Lawrence * . Metabolic Syndrome and Inflammation - Year 3. ABRC (7/1/2008 - 6/30/2009).
  19. Meyer,Christian * Meyer,Christian * Flynn,Charles Robert Mandarino,Lawrence Willis,Wayne Tyrus . Effect of Pioglitazone on Mitochondrial Function in Muscal and Adipose Tissue in Humans. TAKEDA PHARMCLS AMER (5/15/2008 - 3/25/2011).
  20. Mandarino,Lawrence * . Virtual Clinical Research Center. UNIV OF AZ (1/1/2008 - 6/30/2010).
  21. Mandarino,Lawrence * . CTSA Proposal Preparation. BATTELLE MEMORIAL INSTITUTE (8/2/2007 - 12/31/2007).
  22. Mandarino,Lawrence * . Metabolic Syndrome and Inflammation - Year 2. ABRC (7/1/2007 - 6/30/2008).
  23. Mandarino,Lawrence * Mandarino,Lawrence * . Molecular Regulation of Muscle Glucose Metabolism in Man. HHS-NIH-NIDDK (2/1/2007 - 1/31/2012).
  24. Mandarino,Lawrence * . Molecular Regulation of Muscle Glucose Metabolism in Man. HHS-NIH-NIDDK (10/1/2006 - 1/31/2007).
  25. Mandarino,Lawrence * . PGC-1 and Muscle Mitochondrial Dysfunction in Diabetes. HHS-NIH-NIDDK (10/1/2006 - 7/4/2008).
  26. Mandarino,Lawrence * . Metabolic Syndrome and Inflammation. ABRC (7/1/2006 - 6/30/2009).
  27. Mandarino,Lawrence * Mandarino,Lawrence * . ADA Mentor-Based Postdoctoral Fellowship. AMER DIABETES ASSN (7/1/2005 - 6/30/2009).
  28. Mandarino,Lawrence * Mandarino,Lawrence * . Molecular Regulation of Muscle Glucose Metabolism in Man. HHS-NIH-NIDDK (5/1/2005 - 1/31/2007).
  29. Mandarino,Lawrence * Mandarino,Lawrence * . PGC-1 and Muscle Mitochondrial Dysfunction in Diabetes. HHS-NIH-NIDDK (2/1/2005 - 9/30/2006).

* principal investigator

Your profile? You control what’s displayed. Customize your information.

Service

  1. Mayo Clinic Center for Biomedical Discovery, Metabolism Platform leader, member, Steering Committee (2014 - present)
  2. Mayo Clinic Sangre por Salud Biobank, Principal Investigator (2013 - present)
  3. Data Safety and Monitoring Board for "Restore Insulin Secretion" Study. NIH DMSB panel, Review and approve study protocols for this clinical research trial (2012 - present)
  4. Journal of Applied Physiology, Reviewer (2012 - present)
  5. Mayo Clinic Hispanic Biobank, Principal Investigator (2012 - present)
  6. Mayo Clinic Clinical Research Committee, member (2010 - present)
  7. Mayo Clinic Multi-Discipline Oriented Group, member (2010 - present)
  8. Mayo Clinic Research Operations Management Team, member (2010 - present)
  9. Center for Metabolic and Vascular Biology, Director (2009 - present)
  10. Mayo Clinic HEALth Program, Co-Director and Professor of Medicine (2009 - present)
  11. Mayo Clinic HEALth Program, Co-Director and Professor of Medicine (2009 - present)
  12. Mayo Clinic HEALth Program, Co-Director and Professor of Medicine (2009 - present)
  13. Mayo Clinic Health Program, Co-director (2009 - present)
  14. Office of Research and Sponsored Projects, Arizona State University, Member, Self-Study Committee (2006 - present)
  15. Center for Metabolic Biology, Director (2005 - present)
  16. Center for Metabolic Biology, Director (2005 - present)
  17. Center for Metabolic Biology, Director (2005 - present)
  18. Center for Metabolic and Vascular Biology, Director (2005 - present)
  19. Center for Metabolic and Vascular Biology, Director (2005 - present)
  20. Center for Metabolic and Vascular Biology, Director (2005 - present)
  21. Center for Metabolic and Vascular Biology, Director (2005 - present)
  22. Center for Metabolic Biology, Arizona State University, Director (2005 - present)
  23. Department of Kinesiology, Arizona State University, Chair (2005 - present)
  24. Diabetes Journal, Editorial Board (2005 - present)
  25. Kinesiology, Chair (2004 - present)
  26. American Journal of Physiology, Reviewer (1992 - present)
  27. American Journal of Physiology, Reviewer (1992 - present)
  28. Diabetes, Ad hoc reviewer (1987 - present)
  29. Diabetes Care, Ad hoc reviewer (1987 - present)
  30. Journal of Clinical Endocrinology and Metabolism, Reviewer (1987 - present)
  31. Journal of Clinical Endocrinology and Metabolism, Reviewer (1987 - present)
  32. Journal of Clinical Endocrinology and Metabolism, Reviewer (1987 - present)
  33. Diabetes, Reviewer (1985 - present)
  34. Diabetes, Reviewer (1985 - present)
  35. Diabetes, Reviewer (1985 - present)
  36. American Journal of Physiology, reviewer (1982 - present)
  37. Diabetes (journal), Associate Editor (2014)
  38. Diabetes, Associate Editor (2013 - 2014)
  39. Mayo Clinic, Principal Investigator, Sangre por Salud Biobank (2010 - 2014)
  40. Kinesiology, Chair (2004 - 2010)

Your profile? You control what’s displayed. Customize your information.